This product is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.

This product contains 3 medications: aliskiren, amlodipine, and hydrochlorothiazide. Aliskiren is a direct renin inhibitor, and amlodipine is a calcium channel blocker. They both work by relaxing blood vessels so blood can flow more easily. Hydrochlorothiazide is called a "water pill" (diuretic) and causes your body to get rid of extra salt and water by making more urine.

How to Use This Medication

Read the Patient Information Leaflet if available from your pharmacist before you start taking this medication and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually once daily. You may take this medication with or without food, but it is important to choose one way and take this medication the same way with every dose. High-fat foods may decrease how well this drug is absorbed by the body, so it is best to avoid taking this medication with a high-fat meal. Also, if you take this drug too close to bedtime, you may need to wake up to urinate. Therefore, it is best to take this medication at least 4 hours before your bedtime.

Do not take with fruit juices (such as apple, grapefruit, or orange) since they may decrease the absorption of this drug.

The dosage is based on your medical condition and response to treatment.

If you also take certain drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine, colestipol), take aliskiren/amlodipine/hydrochlorothiazide at least 4 hours before or at least 4 to 6 hours after these medications.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick. It may take 2 weeks before you get the full benefit of this medication.

Tell your doctor if your condition does not improve or if it worsens (your blood pressure readings remain high or increase).

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Drug information is selected from data included with permission and copyrighted by First DataBank, Inc. This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional. Always seek the advice of your healthcare professional if you have any questions about this product or your medical condition. This information is not intended as individual medical advice and does not substitute for the knowledge and judgment of your healthcare professional. This information does not contain any assurances that this product is safe, effective or appropriate for you.

This information is intended only for residents of the United States. Products sold under the same brand names in other countries may contain different ingredients.

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Information expires June 2016.